Influenza Master Course

Explore the intricate battle between the human immune system and the influenza virus in this comprehensive course. This course is developed to educate and empower a diverse audience including healthcare professionals, researchers, students, and any proactive individual. You'll learn about the mechanisms of influenza infection and immune response, uncovering critical insights essential for developing effective protocols and prevention strategies from various natural resources.

Spanning four detailed modules, this course takes you on a deep dive into the lifecycle of the influenza virus and the complex immune responses it triggers. Beginning with the virus's initial infection strategies, including spike protein tactics and cellular hijacking, to the sophisticated signaling responses of the body’s innate immunity, and onto the complexities of viral replication, export, and assembly. The course culminates in an exploration of the severe effects of viral propagation, such as induced apoptosis and the dangerous cytokine storms.

Designed for learners eager to understand the nuances of viral infections and immune defenses, this course combines detailed module explorations with cutting-edge scientific discoveries. Participants will gain a rich understanding of how influenza invades human cells, how our bodies fight back at the molecular level, and the latest strategies in influenza research with natural compounds to reverse. Join us to unravel the complexities of immune warfare and arm yourself with knowledge against influenza.

"Anything that's done may be undone in the same manner in which it was done to begin with." - Joseph Phillips

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Presented by Joseph Phillips,
Founder & CEO at DNA Determination Research Consulting.

Joseph has positioned himself at the cutting edge of science and innovation, dedicating over 100,000 hours to researching genes and pathways with natural health solutions. As a self-taught expert in genetics, he has gained recognition from Biochemistry PhDs, Presidents of Naturopathic Medical Schools, and various other professionals in both natural and traditional medicine. He specializes in the complex field of Glycoimmunology which stands at the forefront of health and wellness.

In This Course We Will Cover

Module 1: Initiating Influenza Infection

Part 1: Spike Protein Hijacking, Hemagglutinin (H), & The FURIN Force Neuraminidase (N) & Sweet Sialic Acid Receptors
Part 2: Clathrin Mediated Endocytosis
Part 3: Crossroads of Eukaryotic Translation Initiation Factors
Part 4: Importing Virions Into The Nucleus & The ISG15 Antiviral Mechanism

Module 2: Interferon Antiviral Signaling, Viral RNA Nucleus Integration, & Replication

Part 1: Gain of Function & RNA Interferon Antiviral Immune Responses with MAVS & RNA Sensor RIG-I
Past 2: Pathogen Recognition & Activation of Innate Immunity with Toll-Like Receptors 3, 7, & 8
Part 3: The Treasure Trove of Influenza with The Vault Complex
Part 4: RNA Silencers with DICER, DROSHA, and PASHA

Module 3: Viral Export, Assembly, & Release

Part 1: Exporting Virions Out & RAN GTPases
Part 2: The Calnexin/Calreticulin Cycle & The Endoplasmic Reticulum (ER)
Part 3: Glycosylation & Glycoimmunology
Part 4: Surfactant Proteins & Respiratory Viral Defense
Part 5: Palmitoylation, Fatty Acids, & Lipid Rafts

Module 4: Viral Induced Apoptosis & Cytokine Storms

Part 1: Viral Latency & Transforming Growth Factor Beta 1
Part 2: Mitochondrial Apoptosis & Caspase 3
Part 3: The NLRP3 Inflammasome Nexus
Part 4: Calming The Cytokine Storm with Tumor Necrosis Factor, Interleukin 1 Beta, & Interleukin 6

Influenza Pathways

Importance of Understanding Influenza

Mastering influenza knowledge is more than academic; it's a critical frontline defense in developing advanced therapeutics and preventive measures. Through understanding, there's power—the power to save lives, curb outbreaks, and fortify our global health infrastructure against the inevitable viral threats of tomorrow.

Our structured yet flexible curriculum spans four in-depth modules, each developed to illuminate a particular dimension of the invisible warfare between influenza viruses and our immune system.

Whether you're a medical professional, researcher, student, or simply someone keen on shielding your loved ones and community, this course is your arsenal against the emerging threat.

Module One

Initiating Influenza Infection

For those wanting the abosolute best stratagies for prevention our journey begins at the inception of influenza infection. This module delves into the mechanics of how the influenza virus hijacks human cells to begin with. We explore the key roles of the spike protein, hemagglutinin (H), and neuraminidase (N) in binding to sweet sialic acid receptors on host cells. We investigate the process of clathrin-mediated endocytosis, a critical step for the virus to enter cells, and examine how the virus navigates the cellular machinery to initiate protein synthesis. The fascinating interplay of importing virions into the nucleus and the ISG15 antiviral mechanism is uncovered, setting the stage for the battle to come.

What We'll Cover

Part 1: Spike Protein Hijacking, Hemagglutinin (H), & The FURIN Force Neuraminidase (N) & Sweet Sialic Acid Receptors

Part 2: Clathrin Mediated Endocytosis

Part 3: Crossroads of Eukaryotic Translation Initiation Factors

Part 4: Importing Virions Into The Nucleus & The ISG15 Antiviral Mechanism

Module Two

Gain of Function with Interferon Antiviral Signaling, Viral RNA Nucleus Integration, & Replication

Here we will define stratagies to protect our original DNA Blueprint. At the forefront of the emerging threat is the laboratory "Gain of Function" variation as seen in the H5N1 virus's Polymerase Basic 2 (PB2) protein, which empowers the virus with new capabilities to challenge the host's immune system by interfering with interferon antiviral signaling. As the virus establishes itself, the body attempts to mount its initial defense through interferon antiviral signaling. This module explores how the body recognizes the viral threat with RNA sensors like MAVS and RIG-I and activates innate immunity through toll-like receptors. We’ll take a closer look at the treasure trove of influenza's strategies within the Vault Complex and how RNA silencers like DICER, DROSHA, and PASHA work to mute the invading enemy. This section sets the stage for a comprehensive understanding of how the host's immune system interacts with, disrupts, and aims to neutralize viral intruders at the molecular level.

What We'll Cover

Part 1: Gain of Function & RNA Interferon Antiviral Immune Responses with MAVS & RNA Sensor RIG-I

Past 2: Pathogen Recognition & Activation of Innate Immunity with Toll-Like Receptors 3, 7, & 8

Part 3: The Treasure Trove of Influenza with The Vault Complex

Part 4: RNA Silencers with DICER, DROSHA, and PASHA

Module Three

Viral Export, Assembly, & Release

With the battle in full swing, the influenza virus prepares to spread its influence. This module investigates the processes of viral export, assembly, and release. We cover the crucial steps of exporting virions out of the cell nucleus, the role of the calnexin/calreticulin cycle, the significance of glycosylation in glycoimmunology, the vital aspects of surfactant proteins with respiratory viral defense, and the strategic importance of palmitoylation and lipid rafts in viral assembly.

What We'll Cover

Part 1: Exporting Virions Out & RAN GTPases

Part 2: The Calnexin/Calreticulin Cycle & The Endoplasmic Reticulum (ER)

Part 3: Glycosylation & Glycoimmunology

Part 4: Surfactant Proteins & Respiratory Viral Defense

Part 5: Palmitoylation, Fatty Acids, & Lipid Rafts

Module Four

Viral Induced Apoptosis & Cytokine Storms

In the final leg of our journey, we face the dire consequences of unchecked viral spread: apoptosis and cytokine storms. We dissect the pathways through which the influenza virus can induce cell death, focusing on viral latency with transforming growth factor beta 1 and the mitochondrial pathway involving caspase 3. The module also explores the NLRP3 inflammasome nexus's role in triggering inflammation and how the cytokine storm—a potentially lethal immune response—can be moderated through understanding the roles of tumor necrosis factor, interleukin 1 beta, and interleukin 6.

What We'll Cover

Part 1: Viral Latency & Transforming Growth Factor Beta 1

Part 2: Mitochondrial Apoptosis & Caspase 3

Part 3: The NLRP3 Inflammasome Nexus

Part 4: Calming The Cytokine Storm with Tumor Necrosis Factor, Interleukin 1 Beta, & Interleukin 6

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